Body Research Labs Anadrol 50MG

Oxymetholone

Oxymetholone, sold under the brand names Anadrol and Anapolon among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemia.[3][4] It is also used to treat osteoporosisHIV/AIDS wasting syndrome, and to promote weight gain and muscle growth in certain situations.[3] It is taken by mouth.[3][4]

Side effects of oxymetholone include increased sexual desire as well as symptoms of masculinization like acneincreased hair growth, and voice changes.[3] It can also cause liver damage.[3][4] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[3][5] It has strong anabolic effects and weak androgenic effects.[3]

Oxymetholone was first described in 1959 and was introduced for medical use by 1961.[3][6][7][8] It is used mostly in the United States.[3][9] In addition to its medical use, oxymetholone is used to improve physique and performance.[3] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[3]

Medical uses

The primary clinical applications of oxymetholone include treatment of anemia and osteoporosis, as well as stimulating muscle growth in malnourished or underdeveloped patients.[3] However, in the United States, the only remaining FDA-approved indication is the treatment of anemia.[3][10]

Following the introduction of oxymetholone, nonsteroidal drugs such as epoetin alfa were developed and shown to be more effective as a treatment for anemia and osteoporosis without the side effects of oxymetholone.[3] The drug remained available despite this and eventually found a new use in treating HIV/AIDS wasting syndrome.[3]

Presented most commonly as a 50 mg tablet, oxymetholone has been said to be one of the “strongest” and “most powerful” AAS available for medical use.[3][11] Similarly, there is a risk of side effects.[12][13] Oxymetholone is highly effective in promoting extensive gains in body mass, mostly by greatly improving protein synthesis.[3] For this reason, it is often used by bodybuilders and athletes.[3]

Non-medical uses[edit]

Oxymetholone is used for physique- and performance-enhancing purposes by competitive athletesbodybuilders, and powerlifters.[3]

Side effects

See also: Anabolic steroid § Adverse effects

The common side effects of oxymetholone include depressionlethargyheadacheswelling, rapid weight gainpriapism, changes in skin color, urination problems, nauseavomitingstomach pain (if taken on an empty stomach), loss of appetitejaundicebreast swelling in men, feeling restless or excited, insomnia, and diarrhea.[12] In women, side effects also include acne, changes in menstrual periodsvoice deepeninghair growth on the chin or chestpattern hair lossenlarged clitoris, and changes in libido.[3][12] Because of its 17α-alkylated structure, oxymetholone is hepatotoxic.[3] Long term use of the drug can cause a variety of serious ailments, including hepatitisliver cancer, and cirrhosis; therefore periodic liver function tests are recommended for those taking oxymetholone.[13]

References

  1. Jump up to:a b c d e Saartok T, Dahlberg E, Gustafsson JA (1984). “Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin”. Endocrinology114 (6): 2100–6. doi:10.1210/endo-114-6-2100PMID 6539197.
  2. Jump up to:a b c d e f Maryanne Hochadel; Mosby (1 April 2015). Mosby’s Drug Reference for Health Professions. Elsevier Health Sciences. pp. 1221–. ISBN 978-0-323-31103-8.
  3. Jump up to:a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah William Llewellyn (2011). Anabolics. Molecular Nutrition Llc. pp. 323–334. ISBN 978-0-9828280-1-4.
  4. Jump up to:a b c d e f Pavlatos AM, Fultz O, Monberg MJ, Vootkur A, Pharmd (2001). “Review of oxymetholone: a 17alpha-alkylated anabolic-androgenic steroid”. Clin Ther23 (6): 789–801, discussion 771. doi:10.1016/s0149-2918(01)80070-9PMID 11440282.
  5. ^ Kicman AT (2008). “Pharmacology of anabolic steroids”Br. J. Pharmacol154 (3): 502–21. doi:10.1038/bjp.2008.165PMC 2439524PMID 18500378.
  6. Jump up to:a b Zderic, John A.; Carpio, Humberto; Ringold, H. J. (January 1959). “Steroids. CVI. Synthesis of 7β-Methyl Hormone Analogs”. Journal of the American Chemical Society81 (2): 432–436. doi:10.1021/ja01511a041.
  7. Jump up to:a b “Advertisements” (PDF). Proceedings of the Royal Society of Medicine54 (3). 1961. PMC 1870224.
  8. Jump up to:a b “Advertisements” (PDF). British Medical Journal1 (5224). 1961. PMC 1953122.
  9. Jump up to:a b c d https://www.drugs.com/international/Oxymetholone.html
  10. ^ http://adisinsight.springer.com/drugs/800010476
  11. ^ “Anadrol-50” (PDF). Meda Pharmaceuticals. December 2006. Retrieved 8 January 2012.
  12. Jump up to:a b c “Oxymetholone Side Effects”. drugs.com.
  13. Jump up to:a b “Anadrol Official FDA Information, Side Effects and Uses”. drugs.com.
  14. ^ Hengge UR, Stocks K, Wiehler H, Faulkner S, Esser S, Lorenz C, Jentzen W, Hengge D, Goos M, Dudley RE, Ringham G (2003). “Double-blind, randomized, placebo-controlled phase III trial of oxymetholone for the treatment of HIV wasting”. AIDS17 (5): 699–710. doi:10.1097/00002030-200303280-00008PMID 12646793.
  15. ^ CORTESGALLEGOS, V., CASTANEDA, G., ALONSO, R., PEREZPASTEN, E., REYESLUGO, V., BARRON, C., … & VILLALPANDO, S. (1982, January). SPONTANEOUS AND OXYMETHOLONE-INDUCED GYNECOMASTIA. In JOURNAL OF ANDROLOGY (Vol. 3, No. 1, pp. 33-33). C/O ALLEN PRESS, INC PO BOX 368, LAWRENCE, KS 66044: AMER SOC ANDROLOGY, INC.
  16. ^ VILLALPANDO, S., Mondragon, L., Barron, C., REYESLUGO, U., PEREZPASTEN, E., Alonso, R., … & GALLEGOS, V. (1982, January). 5-ALPHA REDUCTASE BLOCKADE MAY BE RESPONSIBLE FOR SPONTANEOUS AND OXYMETHOLONE-INDUCED GYNECOMASTIA. In ARCHIVOS DE INVESTIGACION MEDICA (Vol. 13, No. 2, pp. S13-S13). SOCIAL APDO POSTAL 73-032, MEXICO DF 03020, MEXICO: INST MEXICANO SEGURO.
  17. Jump up to:a b c J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 924–. ISBN 978-1-4757-2085-3.
  18. Jump up to:a b c d Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 779–. ISBN 978-3-88763-075-1.
  19. ^ Locum, R (1961). “Latest Pharmaceutical Preparations” (PDF). The Central African Journal of Medicine7 (11): 443–444.
  20. ^ CLARK GM (1962). “New drugs in rheumatic disease”. Arthritis Rheum5 (4): 415–8. doi:10.1002/art.1780050411PMID 13879693.
  21. ^ Matusow, Paul D (1962). “If – Then; C.A.M.S.I.; In the future” (PDF). Dalhousie Medical Journal15 (1).
  22. ^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 212–. ISBN 978-94-011-4439-1.
  23. ^ Charles D. Kochakian (6 December 2012). Anabolic-Androgenic Steroids. Springer Science & Business Media. pp. 632–. ISBN 978-3-642-66353-6.
  24. Jump up to:a b “Drugs@FDA: FDA Approved Drug Products”. United States Food and Drug Administration. Retrieved 17 December 2016.
  25. ^ Steven B. Karch, MD, FFFLM (21 December 2006). Drug Abuse Handbook, Second Edition. CRC Press. pp. 30–. ISBN 978-1-4200-0346-8.